Compounds / Metabolic / AICAR

AICAR

AICAR (5-Aminoimidazole-4-carboxamide Ribonucleoside)
MetabolicFDA: Not approved for human useWADA: PROHIBITED — Metabolic...

Overview

Sedentary animals given AICAR showed dramatic endurance improvements. WADA-prohibited metabolic modulator. Not approved for human use.

Mechanism of Action

AMPK activator — 'exercise pill.' Activates AMP-activated protein kinase mimicking exercise-induced metabolic signaling. Increases fatty acid oxidation, glucose uptake, mitochondrial biogenesis.

Molecular Profile

Molecular weight
338.2 Da (small molecule)
CAS number
2627-69-2

Key Research Findings

AMPK activation; endurance enhancement in sedentary animals; 'exercise pill' candidate; WADA-prohibited.

Published Research

Cell (2008)
Narkar VA et al. AMPK and PPARδ agonists are exercise mimetics
View source

Related Metabolic Compounds

SemaglutideTirzepatideRetatrutideCagrilintideMazdutideBioglutide
Clinical Guidance

Research data is not a treatment plan. If you are considering AICAR, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

Speak with a physician LATOM Wellness is a physician-led telehealth practice. Consultation only. No compound is sold on this site.
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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals