Compounds / Other / Dermorphin

Dermorphin

Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2)

OtherFDA: Not approved — Schedule I analogueWADA: PROHIBITED — S7. Narcotics

Overview

Discovered 1981 from frog skin. First natural peptide with D-amino acid. Used as pharmacological tool for opioid receptor research. Illicitly used in horse racing. Classified as controlled substance analogue.

Mechanism of Action

Highly potent mu-opioid receptor agonist (~30-40x morphine). Naturally occurring heptapeptide from South American frog skin. Contains D-Ala conferring enzymatic resistance.

Molecular Profile

Molecular weight

803.9 Da

CAS number

77614-16-5

Key Research Findings

30-40x morphine potency; first natural D-amino acid peptide; Schedule I analogue; NOT for human use.

Published Research

PNAS

Dermorphin: a highly potent opioid peptide from frog skin

View source

Related Other Compounds

PT-141 Melanotan I Melanotan II PNC-27 Cystagen EPO

Clinical Guidance

Research data is not a treatment plan. If you are considering Dermorphin, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator · Full deep dive · Peptide fundamentals