Compounds / GH Axis / HGH (Somatropin)

HGH (Somatropin)

Human Growth Hormone 191aa (Somatropin — Recombinant rHGH)
GH AxisFDA ApprovedFDA: FDA-APPROVED for GH deficiency and...WADA: PROHIBITED — Category S2

Overview

FDA-approved for GH deficiency, Turner syndrome, HIV wasting, multiple other indications. Extensively studied. Compounding and research use outside approved indications is off-label.

Mechanism of Action

Full 191-AA recombinant human GH. Binds GH receptor, activates JAK2-STAT5 signaling, IGF-1 production. Direct anabolic effects. Lipolysis. Bone growth. Protein synthesis.

Molecular Profile

Molecular weight
22,124 Da
CAS number
12629-01-5
Type
Single-chain polypeptide with two disulfide bridges
Length
191 amino acids

Key Research Findings

FDA-approved GHD treatment; IGF-1 elevation; lean mass; fat reduction; bone density.

Published Research

JCEM (2011)
Molitch ME et al. Evaluation and Treatment of Adult GH Deficiency: Endocrine Society Guidelines
View source

Related GH Axis Compounds

IpamorelinCJC-1295 (No DAC)CJC-1295 (DAC)SermorelinTesamorelinGHRP-2
Clinical Guidance

Research data is not a treatment plan. If you are considering HGH (Somatropin), the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals