Compounds / GH Axis / IGF-1 LR3

IGF-1 LR3

IGF-1 Long R3 (Modified IGF-1 Analog — Research Only)
GH AxisLimited ResearchFDA: Not approvedWADA: PROHIBITED — Category S2

Overview

Research compound. Longest-acting IGF-1 analog. Muscle hypertrophy research. Hypoglycemia risk from insulin-like activity. Take with food post-workout.

Mechanism of Action

83-AA IGF-1 variant with 13-AA N-terminal extension and Arg3 substitution. 80× reduced IGFBP binding → increased free fraction. Half-life 20–30h vs ~10 min native IGF-1. Activates IGF-1R for muscle hypertrophy, satellite cell activation, glucose uptake.

Molecular Profile

Molecular weight
9111.5 Da
CAS number
946870-92-4

Key Research Findings

80× reduced IGFBP binding; 20-30h half-life; muscle hypertrophy research; hypoglycemia risk.

Published Research

Prog Growth Factor Res
Ballard FJ et al. Biological actions and therapeutic potential of IGF-1 Long R3
View source

Related GH Axis Compounds

IpamorelinCJC-1295 (No DAC)CJC-1295 (DAC)SermorelinTesamorelinGHRP-2
Clinical Guidance

Research data is not a treatment plan. If you are considering IGF-1 LR3, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

Speak with a physician LATOM Wellness is a physician-led telehealth practice. Consultation only. No compound is sold on this site.
Running IGF-1 LR3? Log doses and track your cycle.

Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals