Compounds / Hormonal / ACTH 1-39

ACTH 1-39

Adrenocorticotropic Hormone (1-39)
HormonalFDA: FDA-APPROVED (H.P. Acthar Gel)WADA: PROHIBITED — S2. Peptide...

Overview

FDA-approved (H.P. Acthar Gel) for infantile spasms, MS exacerbations, and nephrotic syndrome. Anti-inflammatory effects partly independent of adrenal steroidogenesis via melanocortin receptors on immune cells.

Mechanism of Action

Binds melanocortin-2 receptor (MC2R) on adrenal cortex, stimulating cortisol synthesis via cAMP/PKA pathway. Also activates MC1R, MC3R, MC4R, MC5R with anti-inflammatory and immunomodulatory effects independent of cortisol.

Molecular Profile

Molecular weight
4541.1 Da
CAS number
9002-60-2

Key Research Findings

FDA-approved (Acthar Gel); first-line for infantile spasms; nephrotic syndrome; anti-inflammatory via melanocortin receptors; WADA prohibited.

Published Research

Neurology
Treatment of infantile spasms with high-dose ACTH
View source
Trends Endocrinol Metab
Melanocortin receptor-mediated anti-inflammatory effects of ACTH
View source

Related Hormonal Compounds

HCGGonadorelinKisspeptinOxytocinHMGTriptorelin Acetate
Clinical Guidance

Research data is not a treatment plan. If you are considering ACTH 1-39, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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