Compounds / Hormonal / Kisspeptin

Kisspeptin

Kisspeptin (KISS1 Gene Product — Reproductive Neuropeptide)
HormonalEmerging ResearchFDA: Not approvedWADA: Not listed (emerging)

Overview

Central HPG axis regulator. Clinical trials for IVF ovulation trigger, hypothalamic amenorrhea, hypogonadism. Human safety data growing.

Mechanism of Action

Binds GPR54 receptor in hypothalamus → pulsatile GnRH release → downstream LH/FSH secretion. Master upstream regulator of HPG axis. Originally identified as metastasis suppressor (KiSS-1 gene).

Pharmacokinetics

Half-life
28 min
Peak (Tmax)
45 min
Cleared
~2.3 hrs

Molecular Profile

Molecular weight
1,213.42 Da
CAS number
374683-16-6
Type
Neuropeptide family (RFamide)

Key Research Findings

GPR54/GnRH axis master regulator; IVF ovulation trigger; hypothalamic amenorrhea; reproductive health.

Published Research

NEJM (2003)
Seminara SB et al. The GPR54 gene as a regulator of puberty
View source

Related Hormonal Compounds

HCGGonadorelinOxytocinHMGACTH 1-39Triptorelin Acetate
Clinical Guidance

Research data is not a treatment plan. If you are considering Kisspeptin, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

Speak with a physician LATOM Wellness is a physician-led telehealth practice. Consultation only. No compound is sold on this site.
Running Kisspeptin? Log doses and track your cycle.

Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals