Compounds / Hormonal / Triptorelin Acetate

Triptorelin Acetate

Triptorelin Acetate (Trelstar, Decapeptyl — GnRH Agonist)
HormonalFDA: FDA-APPROVED (2000, Trelstar)

Overview

FDA-approved for advanced prostate cancer. Achieves medical castration. Used off-label for endometriosis, precocious puberty, gender-affirming care. Low-dose used as GnRH trigger in IVF.

Mechanism of Action

Synthetic GnRH agonist (D-Trp6 substitution). Initial LH/FSH flare (1-2 weeks), followed by pituitary receptor downregulation causing profound sex steroid suppression to castrate/menopausal levels.

Molecular Profile

Molecular weight
1311.5 Da
CAS number
57773-63-4

Key Research Findings

FDA-approved (Trelstar); testosterone suppression <50 ng/dL; initial flare then suppression; IVF trigger; monthly-to-6mo depot formulations.

Published Research

Eur Urol
Triptorelin for advanced prostate cancer
View source
Hum Reprod Update
GnRH agonist triggering in IVF
View source

Related Hormonal Compounds

HCGGonadorelinKisspeptinOxytocinHMGACTH 1-39
Clinical Guidance

Research data is not a treatment plan. If you are considering Triptorelin Acetate, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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