Compounds / Hormonal / Gonadorelin

Gonadorelin

Gonadorelin (GnRH — Gonadotropin-Releasing Hormone Analog)
HormonalFDA: Previously FDA-approved (Factrel)...WADA: PROHIBITED — Category S2

Overview

Previously FDA-approved (Factrel). Commonly used alongside TRT to preserve HPG axis, testicular function, and fertility. Pulsatile dosing is non-negotiable.

Mechanism of Action

Endogenous GnRH analog. Stimulates pulsatile LH and FSH from anterior pituitary. Maintains HPG axis. CRITICAL: pulsatile dosing essential — continuous infusion causes receptor desensitization and paradoxical SUPPRESSION.

Molecular Profile

Molecular weight
1182.3 Da
CAS number
33515-09-2

Key Research Findings

HPG axis preservation during TRT; LH/FSH stimulation; fertility maintenance; PULSATILE DOSING ESSENTIAL.

Published Research

JCEM
Bhasin S et al. Testosterone Therapy in Men with Hypogonadism: AES Guidelines 2018
View source

Related Hormonal Compounds

HCGKisspeptinOxytocinHMGACTH 1-39Triptorelin Acetate
Clinical Guidance

Research data is not a treatment plan. If you are considering Gonadorelin, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals