Compounds / Hormonal / Clomiphene

Clomiphene

Clomiphene Citrate (Clomid — Selective Estrogen Receptor Modulator)
HormonalFDA: FDA-APPROVED for female ovulatory...WADA: PROHIBITED — Category S4...

Overview

FDA-approved for female ovulatory dysfunction. Extensively used off-label in men for hypogonadism, fertility preservation, and as TRT alternative. Raises testosterone while maintaining fertility — key advantage over exogenous TRT.

Mechanism of Action

Selective estrogen receptor modulator (SERM). Competitively inhibits estrogen binding at hypothalamic ER → removes negative feedback → increases GnRH pulsatility → elevated LH/FSH → stimulates endogenous testosterone production. Preserves HPG axis unlike exogenous testosterone.

Molecular Profile

Molecular weight
598.1 Da
CAS number
50-41-9

Key Research Findings

HPG axis preservation; endogenous testosterone elevation; fertility maintenance; FDA-approved (women); off-label men.

Published Research

Transl Androl Urol (2020)
Krzastek SC et al. Clomiphene citrate for male hypogonadism
View source
J Urol (1996)
Kim ED et al. Clomiphene citrate and its impact on reproductive hormones
View source

Related Hormonal Compounds

HCGGonadorelinKisspeptinOxytocinHMGACTH 1-39
Clinical Guidance

Research data is not a treatment plan. If you are considering Clomiphene, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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