Compounds / Tissue Repair / KPV

KPV

KPV (Lys-Pro-Val — alpha-MSH C-terminal tripeptide)
Tissue RepairEmerging ResearchFDA: Not approved

Overview

Studied for IBD (Crohn's/UC) via oral route. Anti-inflammatory without systemic immunosuppression.

Mechanism of Action

C-terminal alpha-MSH tripeptide. Inhibits NF-κB. Reduces gut inflammation. MC1R activity. Anti-inflammatory without full MSH receptor agonism.

Pharmacokinetics

Half-life
30 min
Peak (Tmax)
15 min
Cleared
~2.5 hrs

Molecular Profile

Molecular weight
340.4 Da
CAS number
69098-83-9

Key Research Findings

NF-κB inhibition; gut anti-inflammatory; IBD preclinical data.

Published Research

Regul Pept (2008)
Kannengiesser K et al. KPV reduces LPS-induced inflammation via NF-kB
View source

Related Tissue Repair Compounds

BPC-157TB-500AHK-CuMGFPEG-MGFKLOW Protocol
Clinical Guidance

Research data is not a treatment plan. If you are considering KPV, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals