Compounds / Tissue Repair / TB-500

TB-500

Thymosin Beta-4 Fragment (Ac-LKKTETQ)
Tissue RepairWell ResearchedFDA: Not approved for human useWADA: PROHIBITED — Category S2

Overview

Preclinical: enhanced collagen deposition, accelerated healing. WADA-prohibited. Extensively studied equine veterinary use. No human RCTs.

Mechanism of Action

G-actin binding drives cell migration. Angiogenesis via VEGF. Reduces inflammation and fibrosis. Prodrug hypothesis: cleaves to active pentapeptide metabolite.

Pharmacokinetics

Half-life
2.5 hrs
Peak (Tmax)
30 min
Cleared
~12.5 hrs

Molecular Profile

Molecular weight
4,963.44 Da
CAS number
77591-33-4
Type
Thymosin fragment
Length
43 amino acids
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-S

Key Research Findings

Angiogenesis; wound healing; collagen deposition; cardiac repair potential.

Published Research

FASEB Journal
Biological activities of thymosin β4 — TB-500 fragment identification
View source
J Chromatography B
Quantification of TB-500 metabolites — prodrug hypothesis
View source

Related Tissue Repair Compounds

BPC-157AHK-CuKPVMGFPEG-MGFKLOW Protocol
Clinical Guidance

Research data is not a treatment plan. If you are considering TB-500, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals