Compounds / Hormonal / Letrozole

Letrozole

Letrozole (Femara — Non-Steroidal Aromatase Inhibitor)
HormonalFDA: FDA-APPROVED (breast cancer in...WADA: PROHIBITED — Category S4

Overview

FDA-approved breast cancer. Off-label fertility induction (often preferred over clomiphene). Off-label in men for hypogonadism. Most aggressive estrogen suppression — requires careful monitoring in men.

Mechanism of Action

Most potent non-steroidal reversible aromatase inhibitor. Reduces estradiol by >99% in postmenopausal women. Triazole derivative — competitive reversible binding to CYP19A1 heme iron. More potent than anastrozole in comparative studies. Used in fertility: stimulates FSH/LH via reduced estrogen feedback.

Molecular Profile

Molecular weight
285.3 Da
CAS number
112809-51-5

Key Research Findings

Most potent AI; >99% E2 reduction; fertility induction off-label; FDA-approved breast cancer; aggressive monitoring needed in men.

Published Research

Expert Opin Pharmacother (2011)
Casper RF. Letrozole: ovulation induction and treatment for infertility
View source

Related Hormonal Compounds

HCGGonadorelinKisspeptinOxytocinHMGACTH 1-39
Clinical Guidance

Research data is not a treatment plan. If you are considering Letrozole, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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