Compounds / Longevity / Epithalon

Epithalon

Epithalon / Epitalon (Ala-Glu-Asp-Gly — Synthetic Pineal Tetrapeptide)
LongevityWell ResearchedFDA: Not approved

Overview

Most studied short peptide for longevity. Human trials: melatonin restoration, improved antioxidant status, telomere elongation markers. Lifespan extension in animal models.

Mechanism of Action

Synthetic tetrapeptide from bovine pineal gland. Activates telomerase (hTERT expression). Modulates pineal melatonin output and circadian rhythm. Antioxidant effects. 35+ years Khavinson research.

Molecular Profile

Molecular weight
390.35 Da
CAS number
307297-39-8
Type
Tetrapeptide
Length
4 amino acids
Ala-Glu-Asp-Gly

Key Research Findings

Telomerase activation; melatonin normalization; antioxidant enhancement; longevity extension in animals; multiple human studies.

Published Research

Bull Exp Biol Med
Khavinson VKh et al. Peptide regulation of aging: 35-year research experience
View source
Bull Exp Biol Med
Anisimov VN et al. Epithalon induces telomerase activity in human somatic cells
View source

Related Longevity Compounds

GHK-CuMOTS-cSS-31FOXO4-DRINAD+Follistatin 344
Clinical Guidance

Research data is not a treatment plan. If you are considering Epithalon, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

Speak with a physician LATOM Wellness is a physician-led telehealth practice. Consultation only. No compound is sold on this site.
Running Epithalon? Log doses and track your cycle.

Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals