Compounds / Longevity / GHK-Cu

GHK-Cu

Copper Peptide GHK-Cu (Glycyl-L-histidyl-L-lysine:Cu²⁺)
LongevityFDA: Not approved as drug; cosmetic...

Overview

Extensive Pickart research group data. Naturally declining levels with age. Strong topical and subcutaneous evidence base. FDA-registered as cosmetic ingredient.

Mechanism of Action

Stimulates collagen, elastin, glycosaminoglycan synthesis. Activates antioxidant enzymes. Upregulates VEGF/FGF. Modulates ~30% of human genes in tissue repair. Nerve regeneration potential.

Pharmacokinetics

Half-life
4 min
Peak (Tmax)
3 min
Cleared
~21 min

Molecular Profile

Molecular weight
404.96 Da
CAS number
49557-75-7
Type
Copper tripeptide
Length
3 amino acids
Gly-His-Lys

Key Research Findings

Collagen/elastin stimulation; antioxidant; wound healing; skin remodeling; neuroprotection.

Published Research

J Aging Res (PMC)
Pickart L et al. GHK-Cu: A Peptide Regulator of Skin Appearance
View source
Int J Mol Sci (PMC)
Pickart L, Margolina A. Regenerative and Protective Actions of GHK-Cu
View source

Related Longevity Compounds

EpithalonMOTS-cSS-31FOXO4-DRINAD+Follistatin 344
Clinical Guidance

Research data is not a treatment plan. If you are considering GHK-Cu, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Running GHK-Cu? Log doses and track your cycle.

Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals