Molecular weight
802.1 Da
Most studied cosmeceutical peptide. Clinical studies show 27-44% reduction in wrinkle depth after 4 months. Comparable to retinol without irritation. Developed by Sederma (Croda).
Lipopeptide from procollagen I C-terminal propeptide. Penetrates skin via palmitoyl moiety, activates fibroblasts by mimicking matrikines. Stimulates collagen I, III, IV, fibronectin, and hyaluronic acid via TGF-beta signaling.
27-44% wrinkle reduction; stimulates collagen synthesis; palmitoyl increases penetration 6x; retinol-comparable efficacy.
Research data is not a treatment plan. If you are considering Matrixyl, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.
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Reconstitution calculator · Full deep dive · Peptide fundamentals