Compounds / Tissue Repair / Thymosin Beta-4

Thymosin Beta-4

Thymosin Beta-4 (Tβ4 — Full 43-AA Native Peptide)
Tissue RepairWell ResearchedFDA: Not approvedWADA: PROHIBITED — Category S2

Overview

Phase I human IV safety study in healthy volunteers (excellent profile). Phase II cardiac trial (EPC pre-treatment). Full molecule vs TB-500 fragment debate in research community.

Mechanism of Action

Full 43-AA thymosin beta-4. Binds G-actin, promoting cell migration. Promotes angiogenesis, wound healing, anti-inflammatory effects. TB-500 is the Ac-LKKTETQ bioactive N-terminal fragment responsible for most effects. IV use in Phase I/II clinical trials (cardiac).

Molecular Profile

Molecular weight
4,963.44 Da
CAS number
77591-33-4
Type
Thymosin peptide
Length
43 amino acids
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-S

Key Research Findings

Full molecule; G-actin binding; Phase I/II human trials; cardiac applications; TB-500 is the bioactive fragment.

Published Research

FASEB J (2012)
Goldstein AL et al. Thymosin beta4: actin-sequestering protein with multiple biological activities
View source

Related Tissue Repair Compounds

BPC-157TB-500AHK-CuKPVMGFPEG-MGF
Clinical Guidance

Research data is not a treatment plan. If you are considering Thymosin Beta-4, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

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Interactive tools for this compound:

Reconstitution calculator  ·  Full deep dive  ·  Peptide fundamentals