Compounds / Longevity / Humanin

Humanin

Humanin (Mitochondrial-Derived Peptide — 21 AA)

LongevityFDA: Not approved; research compound

Overview

Second mitochondrial-derived peptide after MOTS-c. Neuroprotection from amyloid-beta toxicity. Age-related decline. Cytoprotective effects across multiple tissues.

Mechanism of Action

21-AA mitochondrial-derived peptide (12S rRNA encoded, like MOTS-c). Neuroprotective: inhibits Alzheimer's-associated neurotoxicity. Anti-apoptotic. Cytoprotective. Declines with age. Works via FPRL1/CLR/RAMP receptors.

Molecular Profile

Molecular weight

~2432 Da

Key Research Findings

Mitochondrial-derived; neuroprotection; anti-apoptotic; amyloid-beta protection; age-related decline.

Published Research

PNAS (2001)

Hashimoto Y et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta

View source

Related Longevity Compounds

GHK-Cu Epithalon MOTS-c SS-31 FOXO4-DRI NAD+

Clinical Guidance

Research data is not a treatment plan. If you are considering Humanin, the questions that matter are whether it suits your history, your labs and your goals. That is a conversation with a licensed physician, not a lookup.

Speak with a physician LATOM Wellness is a physician-led telehealth practice. Consultation only. No compound is sold on this site.

Running Humanin? Log doses and track your cycle.

Interactive tools for this compound:

Reconstitution calculator · Full deep dive · Peptide fundamentals